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KMID : 1134820120410050612
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 5 p.612 ~ p.620
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Repeated-Dose Oral Toxicity Study of Lactobacillus Plantarum AF1 Isolated from Kimchi in Rats
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Lee Jae-Joon
Kim Ah-Ra
Chang Hae-Choon
Lee Myong-Ryeol
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Abstract
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This study was performed to investigate the 4-week repeated-dose toxicity of Lactobacillus plantarum AF1 (Lb. plantarum AF1), a lactic acid bacteria isolated from kimchi, in male and female rats. Sprague-Dawley male and female rats were divided into four groups, with 10 animals in each group. The test article was administered once daily by gavage to rats at dosage levels of 0, 0.5, 1.0, and 2.0 g/kg/day for 4-weeks. There were no test article- related deaths or abnormal clinical signs in either gender of rat during the observation period. Furthermore, no differences were found between the control and treatment groups in terms of body weight changes, food intake, and water consumptions. Hematological parameters, serum biochemical analysis, and any other findings also showed no significant or dose-dependent alterations. There were no alterations in organ weights upon administration of Lb. plantarum AF1. These results suggest that there were no adverse effects of oral application of Lb. plantarum AF1 up to a dosage level of 2.0 g/kg in both male and female rats.
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KEYWORD
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Lactobacillus plantarum AF1, repeated four-week oral toxicity, rats
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